Protein Details: Potassium channel subfamily K member 4

Function

Voltage-insensitive potassium channel. Channel opening is triggered by mechanical forces that deform the membrane; and by raising the intracellular pH to basic levels. The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening; with a further increase in channel activity when the temperature is raised to 42 degrees Celsius. Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure (By similarity).

Sequence

PDB Structures

Ligand Binding